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Article

U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis.

RNA (New York, N.Y.) - 1 Mar 2006

Godfrey Ashley C, Kupsco Jeremy M, Burch Brandon D, Zimmerman Ryan M, Dominski Zbigniew, Marzluff William F, Duronio Robert J

Abstract excerpt

Metazoan replication-dependent histone mRNAs are not polyadenylated, and instead terminate in a conserved stem-loop structure generated by an endonucleolytic cleavage involving the U7 snRNP, which interacts with histone pre-mRNAs through base-pairing between U7 snRNA and a purine-rich sequence in the pre-mRNA located downstream of the cleavage site. Here we generate null mutations of the single Drosophila U7 gene...

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Identifiers

PMID: 16495235
DOI: 10.1261/rna.2270406
PMCID: PMC1383579

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SLBP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis.PMID 16495235Read ↗

The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development.Semantic proximity Read ↗

Differences and similarities between Drosophila and mammalian 3' end processing of histone pre-mRNAs.Semantic proximity Read ↗

Loss of the histone pre-mRNA processing factor stem-loop binding protein in Drosophila causes genomic instability and impaired cellular proliferation.Semantic proximity Read ↗

Multiple processing-defective mutations in a mammalian histone pre-mRNA are suppressed by compensatory changes in U7 RNA both in vivo and in vitro.Semantic proximity Read ↗

Drosophila stem loop binding protein coordinates accumulation of mature histone mRNA with cell cycle progression.Semantic proximity Read ↗

Multiple Quality Control Checkpoints Safeguard Small Nuclear RNA Biogenesis and Prevent Assembly of Aberrant SpliceosomesSemantic proximity Read ↗

A complex containing the CPSF73 endonuclease and other polyadenylation factors associates with U7 snRNP and is recruited to histone pre-mRNA for 3'-end processing.Semantic proximity Read ↗

Concentrating pre-mRNA processing factors in the histone locus body facilitates efficient histone mRNA biogenesis.Semantic proximity Read ↗

Drosophila Symplekin localizes dynamically to the histone locus body and tricellular junctions.Semantic proximity Read ↗

U7 snRNP is recruited to histone pre-mRNA in a FLASH-dependent manner by two separate regions of the stem-loop binding protein.Semantic proximity Read ↗

Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA.Semantic proximity Read ↗

The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs.Semantic proximity Read ↗

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