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Article

Macrophage as a Peripheral Pain Regulator.

Cells - 24 Jul 2021

Domoto Risa, Sekiguchi Fumiko, Tsubota Maho, Kawabata Atsufumi

Abstract excerpt

A neuroimmune crosstalk is involved in somatic and visceral pathological pain including inflammatory and neuropathic components. Apart from microglia essential for spinal and supraspinal pain processing, the interaction of bone marrow-derived infiltrating macrophages and/or tissue-resident macrophages with the primary afferent neurons regulates pain signals in the peripheral tissue. Recent studies have uncovered...

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Identifiers

PMID: 34440650
DOI: 10.3390/cells10081881
PMCID: PMC8392675

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