Article
The tumor suppressor gene, lethal(2)giant larvae (1(2)g1), is required for cell shape change of epithelial cells during Drosophila development.
Development (Cambridge, England) - 1 Jul 1996
Manfruelli P, Arquier N, Hanratty W P, Sémériva M
Abstract excerpt
Inactivation of the lethal(2)giant larvae (l(2)gl) gene results in malignant transformation of imaginal disc cells and neuroblasts of the larval brain in Drosophila. Subcellular localization of the l(2)gl gene product, P127, and its biochemical characterization have indicated that it participates...
Topics
- Alleles
- Animals
- Cell Size
- Drosophila
- Drosophila Proteins
- Embryo, Nonmammalian
- Epithelial Cells
- Epithelium
- Female
- Genes, Insect
- Genes, Tumor Suppressor
- Immunohistochemistry
- In Situ Hybridization
- Insect Hormones
- Intestine, Small
- Larva
- Mutagenesis, Site-Directed
- Mutation