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Article

Runx1 Transcription Factor Is Required for Myoblasts Proliferation during Muscle Regeneration

14 Aug 2015

Abstract excerpt

Following myonecrosis, muscle satellite cells proliferate, differentiate and fuse, creating new myofibers. The Runx1 transcription factor is not expressed in naïve developing muscle or in adult muscle tissue. However, it is highly expressed in muscles exposed to myopathic damage yet, the role of Runx1 in muscle regeneration is completely unknown. Our study of Runx1 function in the muscle's response to myonecrosis...

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PMID: 26275053
DOI: 10.1371/journal.pgen.1005457

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