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Article

Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy.

The Journal of cell biology - 15 Dec 2008

Cowling Belinda S, McGrath Meagan J, Nguyen Mai-Anh, Cottle Denny L, Kee Anthony J, Brown Susan, Schessl Joachim, Zou Yaqun, Joya Josephine, Bönnemann Carsten G, Hardeman Edna C, Mitchell Christina A

Abstract excerpt

Regulators of skeletal muscle mass are of interest, given the morbidity and mortality of muscle atrophy and myopathy. Four-and-a-half LIM protein 1 (FHL1) is mutated in several human myopathies, including reducing-body myopathy (RBM). The normal function of FHL1 in muscle and how it causes myopathy remains unknown. We find that FHL1 transgenic expression in mouse skeletal muscle promotes hypertrophy and an...

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Identifiers

PMID: 19075112
DOI: 10.1083/jcb.200804077
PMCID: PMC2600747

Genes

FHL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy.PMID 19075112Read ↗

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Reducing body myopathy and other FHL1-related muscular disorders.Semantic proximity Read ↗

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Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: a comprehensive review of the clinical, histological and pathological features.Semantic proximity Read ↗

Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.Semantic proximity Read ↗

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