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Article

Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy.

The Journal of cell biology - 15 Dec 2008

Cowling Belinda S, McGrath Meagan J, Nguyen Mai-Anh, Cottle Denny L, Kee Anthony J, Brown Susan, Schessl Joachim, Zou Yaqun, Joya Josephine, Bönnemann Carsten G, Hardeman Edna C, Mitchell Christina A

Abstract excerpt

Regulators of skeletal muscle mass are of interest, given the morbidity and mortality of muscle atrophy and myopathy. Four-and-a-half LIM protein 1 (FHL1) is mutated in several human myopathies, including reducing-body myopathy (RBM). The normal function of FHL1 in muscle and how it causes myopat...

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Source

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Identifiers

PMID: 19075112
DOI: 10.1083/jcb.200804077
PMCID: PMC2600747

Genes

FHL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19075112-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Identification of FHL1 as a regulator of skeletal muscle mass: implications for human myopathy.PMID 19075112Read ↗

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Four and a half LIM protein 1 gene mutations cause four distinct human myopathies: a comprehensive review of the clinical, histological and pathological features.Semantic proximity Read ↗

Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly.Semantic proximity Read ↗

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