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Article

A model analysis for dose-response relationship of warfarin in Japanese children: An introduction of the SIZE parameter.

Drug metabolism and pharmacokinetics - 1 Jun 2016

Nakamura Saki, Watanabe Nao, Yoshimura Naoki, Ozawa Sayaka, Hirono Keiichi, Ichida Fukiko, Taguchi Masato

Abstract excerpt

The objective of the present study was to develop an optimal equation for the pediatric dose-response relationship of warfarin using a size parameter with an exponent of body weight (SIZE) which has been proposed for scaling drug clearance. Twenty patients with stable anticoagulation by warfarin were enrolled in the present study. During a mean follow-up period of 7.36 years, 857 data points were obtained. The...

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Source

Identifiers

PMID: 27234489
DOI: 10.1016/j.dmpk.2016.03.007

Genes

VKORC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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