Predicting the “First dose in children” of CYP3A‐metabolized drugs: Evaluation of scaling approaches and insights into the CYP3A7‐CYP3A4 switch at young ages

Abstract excerpt

First-dose-in-children relies on the prediction of clearance from adults for which little information is available on the accuracy of the scaling-approaches applied. For CYP3A-metabolized compounds, scaling of clearance is further challenged by different isoforms and by the CYP3A7 to CYP3A4 switch at young ages. This investigation aimed to evaluate the accuracy of two frequently used scaling approaches and to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Pharmaceutical studies and practices
• Share to Pharmacogenetics and Drug Metabolism
• Share to Statistical Methods in Clinical Trials