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Article

Influence of CYP4F2 polymorphisms and plasma vitamin K levels on warfarin sensitivity in Japanese pediatric patients.

Drug metabolism and pharmacokinetics - 1 Jan 2013

Hirai Keita, Hayashi Hideki, Ono Yasuo, Izumiya Kohei, Tanaka Masaki, Suzuki Takayo, Sakamoto Tatsuichiro, Itoh Kunihiko

Abstract excerpt

The aim of this study was to reveal the contribution of CYP4F2, CYP2C9, and VKORC1 genetic polymorphisms on the pharmacokinetics and pharmacodynamics of warfarin in Japanese pediatric patients. Genetic analyses of CYP4F2 (rs2108622), CYP2C9 (*2 and *3), and VKORC1 (-1639G>A) were performed, and p...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C9

Share to Cytochrome P450 Family 4

Share to Metabolism, Inborn Errors

Share to Vitamin K 2

Share to Vitamin K Epoxide Reductases

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Source

Identifiers

PMID: 22892446
DOI: 10.2133/dmpk.dmpk-12-rg-078

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22892446-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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