Article
Population pharmacokinetics of theophylline in premature Korean infants.
Therapeutic drug monitoring - 1 Jun 2013
Kim Sung Eun, Kim Bo-Hyung, Lee Seunghwan, Sohn Jin A, Kim Han-Suk, Cho Joo-Youn, Yoon Seo Hyun, Jang In-Jin, Yu Kyung-Sang, Lim Kyoung Soo
Abstract excerpt
OBJECTIVES: The aim of this study was to investigate the population pharmacokinetics of theophylline in premature Korean infants and to assess the influence of clinical covariates. METHODS: Blood samples were first obtained after 1 week of maintenance dosing and then acquired approximately 4 weeks after continuous dosing. The time points were just before dosing and 2, 4, or 6 hours (at randomly assigned time...
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