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Article

Follistatin‐like 1 promotes cardiac fibroblast activation and protects the heart from rupture

27 May 2016

Abstract excerpt

Follistatin-like 1 (Fstl1) is a secreted protein that is acutely induced in heart following myocardial infarction (MI). In this study, we investigated cell type-specific regulation of Fstl1 and its function in a murine model of MI Fstl1 was robustly expressed in fibroblasts and myofibroblasts in the infarcted area compared to cardiac myocytes. The conditional ablation of Fstl1 in S100a4-expressing fibroblast...

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Share to Cardiac Fibrosis and Remodeling
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Identifiers

PMID: 27234440
DOI: 10.15252/emmm.201506151

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