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Article

Absence of UCHL 1 function leads to selective motor neuropathy

7 Mar 2016

Abstract excerpt

OBJECTIVE: The aim of this study was to investigate the role of ubiquitin C-terminal hydrolase-L1 (UCHL1) for motor neuron circuitry and especially in spinal motor neuron (SMN) health, function, and connectivity. METHODS: Since mutations in UCHL1 gene leads to motor dysfunction in patients, we investigated the role of UCHL1 on SMN survival, axon health, and connectivity with the muscle, by employing molecular and...

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Identifiers

PMID: 27231703
DOI: 10.1002/acn3.298

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