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Article

Ubiquitin carboxyl-terminal hydrolase L1 is required for maintaining the structure and function of the neuromuscular junction.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jan 2010

Chen Fujun, Sugiura Yoshie, Myers Kalisa Galina, Liu Yun, Lin Weichun

Abstract excerpt

The enzyme ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1) is one of the most abundant proteins in the mammalian nervous system. In humans, UCH-L1 is also found in the ubiquitinated inclusion bodies that characterize neurodegenerative diseases in the brain, suggesting its involvement in neurodegeneration. The physiologic role of UCH-L1 in neurons, however, remains to be further elucidated. For example, previous...

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Identifiers

PMID: 20080621
DOI: 10.1073/pnas.0911516107
PMCID: PMC2824399

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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