ALS mouse model SOD1G93Adisplays early pathology of sensory small fibers associated to accumulation of a neurotoxic splice variant of peripherin

Abstract excerpt

Growing evidence suggests that amyotrophic lateral sclerosis (ALS) is a multisystem neurodegenerative disease that primarily affects motor neurons and, though less evidently, other neuronal systems. About 75% of sporadic and familial ALS patients show a subclinical degeneration of small-diameter fibers, as measured by loss of intraepidermal nerve fibers (IENFs), but the underlying biological causes are unknown....

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