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Article

Abolishing UCHL1's hydrolase activity exacerbates TBI-induced axonal injury and neuronal death in mice.

Experimental neurology - 1 Feb 2021

Mi Zhiping, Liu Hao, Rose Marie E, Ma Xiecheng, Reay Daniel P, Ma Jie, Henchir Jeremy, Dixon C Edward, Graham Steven H

Abstract excerpt

Ubiquitin (Ub) C-terminal hydrolase L1 (UCHL1) is a multifunctional protein that is expressed in neurons throughout brain at high levels. UCHL1 deletion is associated with axonal degeneration, progressive sensory motor ataxia, and premature death in mice. UCHL1 has been hypothesized to play a role in the pathogenesis of neurodegenerative diseases and recovery after neuronal injury. UCHL1 hydrolyzes Ub from...

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Identifiers

PMID: 33159930
DOI: 10.1016/j.expneurol.2020.113524
PMCID: PMC7855818

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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