Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms.

Abstract excerpt

Mutations in the ALS2 gene result in early-onset amyotrophic lateral sclerosis, infantile-onset ascending hereditary spastic paraplegia and juvenile primary lateral sclerosis, suggesting prominent upper motor neuron involvement. However, the importance of alsin function for corticospinal motor neuron (CSMN) health and stability remains unknown. To date, four separate alsin knockout (Alsin(KO)) mouse models have...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Axons
• Share to Cerebral Cortex