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Article

Genetics of autosomal mosaic chromosomal alteration (mCA).

Journal of human genetics - 1 Sept 2021

Liu Xiaoxi, Kamatani Yoichiro, Terao Chikashi

Abstract excerpt

Mosaic chromosomal alterations (mCAs) are frequently observed in cancer cells and are regarded as one of the common features of cancers. Strikingly, accumulating studies demonstrated that mCAs are also prevalent in elderly individuals without cancer, implying mCA could be a feature of aging and not necessarily a cancerous state. However, the genetic basis of mCA has been mostly unknown. Recent studies of...

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PMID: 34321609
DOI: 10.1038/s10038-021-00964-4

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