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Progressive accumulation of mutations in the hepatitis B virus genome and its impact on time to diagnosis of hepatocellular carcinoma.

Hepatology (Baltimore, Md.) - 1 Sept 2016

Sung Feng-Yu, Lan Chia-Ying, Huang Chi-Jung, Lin Chih-Lin, Liu Chun-Jen, Chen Pei-Jer, Lin Shi-Ming, Yu Ming-Whei

Abstract excerpt

UNLABELLED: To evaluate how hepatitis B virus (HBV) genetic variation affected progression from chronic carrier state to hepatocellular carcinoma (HCC), we analyzed HBV full-length sequences in blood obtained <1-20 years before diagnosis from 117 HCC cases and 118 controls nested in a cohort of 4,841 HBV carriers, for whom HBV genotypes B and C are predominant. The relationship between each viral...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 27228506
DOI: 10.1002/hep.28654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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