Article
Genome-wide association study identifies new loci associated with risk of HBV infection and disease progression.
BMC medical genomics - 18 Mar 2021
Zeng Zheng, Liu Hankui, Xu Huifang, Lu Haiying, Yu Yanyan, Xu Xiaoyuan, Yu Min, Zhang Tao, Tian Xiulan, Xi Hongli, Guan Liping, Zhang Jianguo, O'Brien Stephen J
Abstract excerpt
BACKGROUND: Recent studies have identified susceptibility genes of HBV clearance, chronic hepatitis B, liver cirrhosis, hepatocellular carcinoma, and showed the host genetic factors play an important role in these HBV-related outcomes. METHODS: Collected samples from different outcomes of HBV infection and performed genotyping by Affymetrix 500 k SNP Array. GCTA tool, PLINK, and Bonferroni method were applied for...
Topics
- Humans
- Genome-Wide Association Study
- Disease Progression
- Polymorphism, Single Nucleotide
- Male
- Female
- Genetic Predisposition to Disease
- Middle Aged
- Case-Control Studies
- Adult
- Hepatitis B, Chronic
- Carcinoma, Hepatocellular