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Article

Worldwide genetic diversity of HBV genotypes and risk of hepatocellular carcinoma.

Cancer letters - 1 Dec 2009

Pujol Flor Helene, Navas Maria-Cristina, Hainaut Pierre, Chemin Isabelle

Abstract excerpt

Hepatitis B viruses (HBV) are responsible for over 50% of the worldwide attributable risk of hepatocellular carcinoma (HCC) and this figure increases even further in regions of high endemicity. Systematic sequencing of HBV genomes has identified that this common virus existed as eight distinct genotypes (denoted A-H), each regrouping variants with less than 8% divergence in their DNA sequence. These genotypes...

Topics

Carcinoma, Hepatocellular
Genetic Variation
Genome, Viral
Genotype
Hepatitis B virus
Humans
Liver Neoplasms
Mutation
Promoter Regions, Genetic
Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19683385
DOI: 10.1016/j.canlet.2009.07.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19683385-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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