Article
Novel point and combo-mutations in the genome of hepatitis B virus-genotype D: characterization and impact on liver disease progression to hepatocellular carcinoma.
PloS one - 1 Jan 2014
Datta Somenath, Ghosh Alip, Dasgupta Debanjali, Ghosh Amit, Roychoudhury Shrabasti, Roy Gaurav, Das Soumyojit, Das Kausik, Gupta Subash, Basu Keya, Basu Analabha, Datta Simanti, Chowdhury Abhijit, Banerjee Soma
Abstract excerpt
BACKGROUND: The contribution of chronic hepatitis B virus (HBV) infection in the pathogenesis of hepatocellular carcinoma (HCC) through progressive stages of liver fibrosis is exacerbated by the acquisition of naturally occurring mutations in its genome. This study has investigated the prevalence of single and combo mutations in the genome of HBV-genotype D from treatment naïve Indian patients of progressive...
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