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Article

Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion.

PLoS genetics - 1 May 2016

Wu Zuopeng, Liang Rong, Ohnesorg Thomas, Cho Vicky, Lam Wesley, Abhayaratna Walter P, Gatenby Paul A, Perera Chandima, Zhang Yafei, Whittle Belinda, Sinclair Andrew, Goodnow Christopher C, Field Matthew, Andrews T Daniel, Cook Matthew C

Abstract excerpt

Most humans harbor both CD177neg and CD177pos neutrophils but 1-10% of people are CD177null, placing them at risk for formation of anti-neutrophil antibodies that can cause transfusion-related acute lung injury and neonatal alloimmune neutropenia. By deep sequencing the CD177 locus, we catalogued CD177 single nucleotide variants and identified a novel stop codon in CD177null individuals arising from a single base...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27227454
DOI: 10.1371/journal.pgen.1006067
PMCID: PMC4882059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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