Article
The CD177 c.1291A Allele Leads to a Loss of Membrane Expression and Mimics a CD177-Null Phenotype.
International journal of molecular sciences - 1 Mar 2024
Traum Annalena, Jehle Stefanie, Waxmann Yannick, Litmeyer Anne-Sophie, Berghöfer Heike, Bein Gregor, Dammann Reinhard, Perniss Alexander, Burg-Roderfeld Monika, Sachs Ulrich J, Bayat Behnaz
Abstract excerpt
CD177 is a glycosyl phosphatidyl inositol (GPI)-linked, neutrophil-specific glycoprotein that in 3-5% of normal individuals is absent from all neutrophils. The molecular mechanism behind the absence of CD177 has not been unravelled completely. Here, we analyse the impact of the recently described CD177 c.1291G>A variant on CD177 expression. Recombinant CD177 c.1291G>A was expressed in HEK293F cells and its...
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