Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic mechanism of human neutrophil antigen 2 deficiency and expression variations.

PLoS genetics - 1 May 2015

Li Yunfang, Mair David C, Schuller Randy M, Li Ling, Wu Jianming

Abstract excerpt

Human neutrophil antigen 2 (HNA-2) deficiency is a common phenotype as 3-5% humans do not express HNA-2. HNA-2 is coded by CD177 gene that associates with human myeloproliferative disorders. HNA-2 deficient individuals are prone to produce HNA-2 alloantibodies that cause a number of disorders including transfusion-related acute lung injury and immune neutropenia. In addition, the percentages of HNA-2 positive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation
Share to Genetic Diseases, Inborn
Share to GPI-Linked Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Healthy Volunteers

Share to Isoantigens

Share to Neutrophils

Share to Receptors, Cell Surface

Share to Sequence Deletion

Source

Open in PubMed Open full text

Identifiers

PMID: 26024230
DOI: 10.1371/journal.pgen.1005255
PMCID: PMC4449163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic mechanism of human neutrophil antigen 2 deficiency and expression variations.PMID 26024230Read ↗

An accurate genetic assay to identify human neutrophil antigen 2 deficiency.Semantic proximity Read ↗

Molecular studies reveal that A134T, G156A and G1333A SNPs in the CD177 gene are associated with atypical expression of human neutrophil antigen-2.Semantic proximity Read ↗

A novel nonsense mutation found in the CD177 gene of Thai individuals with the HNA-2 null phenotype.Semantic proximity Read ↗

Heterogeneity of Human Neutrophil CD177 Expression Results from CD177P1 Pseudogene Conversion.Semantic proximity Read ↗

Neutrophil-specific antigen HNA-2a (NB1, CD177): serology, biochemistry, and molecular biology.Semantic proximity Read ↗

Molecular Genetics of the Human Neutrophil AntigensSemantic proximity Read ↗

Molecular basis of NB1 (HNA-2a, CD177) deficiency.Semantic proximity Read ↗

Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets.Semantic proximity Read ↗

Flow-Cytometric Analysis of HNA-2 Expression and Phenotypes Among Thai Blood Donors.Semantic proximity Read ↗

A sequence-specific polymerase chain reaction method for HNA-2 genotyping: homozygous c.843A>T mutation predicts the absence of CD177.Semantic proximity Read ↗

Neutrophil alloantigens.Semantic proximity Read ↗

Human neutrophil antigens: Nature, clinical significance and detection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.