Article
Neutrophil transmigration mediated by the neutrophil-specific antigen CD177 is influenced by the endothelial S536N dimorphism of platelet endothelial cell adhesion molecule-1.
Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2010
Bayat Behnaz, Werth Silke, Sachs Ulrich J H, Newman Debra K, Newman Peter J, Santoso Sentot
Abstract excerpt
The human neutrophil-specific adhesion molecule CD177 (also known as the NB1 alloantigen) becomes upregulated on the cell surface in a number of inflammatory settings. We recently showed that CD177 functions as a novel heterophilic counterreceptor for the endothelial junctional protein PECAM-1 (CD31), an interaction that is mediated by membrane-proximal PECAM-1 IgD 6, which is known to harbor an S(536)N single...
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