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Article

miR-219 regulates neural progenitors by dampening apical Par protein-dependent Hedgehog signaling.

Development (Cambridge, England) - 1 Jul 2016

Hudish Laura I, Galati Domenico F, Ravanelli Andrew M, Pearson Chad G, Huang Peng, Appel Bruce

Abstract excerpt

The transition of dividing neuroepithelial progenitors to differentiated neurons and glia is essential for the formation of a functional nervous system. Sonic hedgehog (Shh) is a mitogen for spinal cord progenitors, but how cells become insensitive to the proliferative effects of Shh is not well understood. Because Shh reception occurs at primary cilia, which are positioned within the apical membrane of...

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Identifiers

PMID: 27226318
DOI: 10.1242/dev.137844
PMCID: PMC4958328

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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