Article
A critical role for sonic hedgehog signaling in the early expansion of the developing brain.
Nature neuroscience - 1 Feb 2002
Britto Joanne, Tannahill David, Keynes Roger
Abstract excerpt
The mechanisms that coordinate the three-dimensional shape of the vertebrate brain during development are largely unknown. We have found that sonic hedgehog (Shh) is crucial in driving the rapid, extensive expansion of the early vesicles of the developing midbrain and forebrain. Transient displacement of the notochord from the midbrain floor plate resulted in abnormal folding and overall collapse of the vesicles,...
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