Article

Lipogenesis-driven EGFR palmitoylation enables metastatic immune evasion in triple-negative breast cancer

2026-05-26

Abstract excerpt

Metastasis is the leading cause of death in triple-negative breast cancer (TNBC), yet how tumor cells evade immune recognition during dissemination remain unclear. Here, we show that de novo lipogenesis drives metastatic immune evasion through FASN-mediated palmitoylation of EGFR. This modification establishes a lipid-dependent membrane signaling scaffold that sustains PI3K-AKT-mTOR signaling independently of MAPK...

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Literature Corpus work: c94f0c94-934b-557a-998b-1ef9a127a775
DOI: 10.64898/2026.05.21.726063

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