Article
Normal mammary fibroblasts induce reversion of the malignant phenotype in human primary breast cancer.
Anticancer research - 1 Apr 2013
Römer Anna-Maria, Lühr Inke, Klein Andreas, Friedl Andreas, Sebens Susanne, Rösel Frank, Arnold Norbert, Strauss Alexander, Jonat Walter, Bauer Maret
Abstract excerpt
BACKGROUND/AIM: The tumor microenvironment plays a major role in tumor growth and progression. Its manipulation can lead to a reversion of the malignant phenotype. Here we explored the ability of normal mammary fibroblasts (HMFs) to induce reversion of the malignant phenotype of primary breast carcinoma cells (PBCs) in a three-dimensional (3D) context. MATERIALS AND METHODS: PBCs were isolated from 13 primary...
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