Article
Interaction of immunological genes on chromosome 2q33 and IFNG in susceptibility to cervical cancer.
Gynecologic oncology - 1 Mar 2010
Ivansson Emma L, Juko-Pecirep Ivana, Gyllensten Ulf B
Abstract excerpt
OBJECTIVE: Cervical cancer is caused by persistent infection with human papillomavirus and genetic susceptibility factors may augment disease risk. The immune response consists of complex interactions and it was recently proposed that the association of combinations of genotypes at several genes should be examined. In support of this the combination CD28+17(TT)/IFNG+874(AA) was shown to increase cervical cancer...
Topics
- Antigens, CD
- Antigens, Differentiation, T-Lymphocyte
- CD28 Antigens
- CTLA-4 Antigen
- Chromosomes, Human, Pair 2
- Female
- Gene Frequency
- Genetic Predisposition to Disease
- Genotype
- Haplotypes
- Humans
- Inducible T-Cell Co-Stimulator Protein
- Interferon-gamma
- Polymorphism, Single Nucleotide
- Uterine Cervical Neoplasms