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Article

Regulation of the Ste20-like kinase, SLK: involvement of activation segment phosphorylation.

The Journal of biological chemistry - 17 Feb 2012

Luhovy Artem Y, Jaberi Aala, Papillon Joan, Guillemette Julie, Cybulsky Andrey V

Abstract excerpt

Expression and activation of the Ste20-like kinase, SLK, is increased during kidney development and recovery from ischemic acute kidney injury. SLK promotes apoptosis, and it may regulate cell survival during injury or repair. This study addresses the role of phosphorylation in the regulation of kinase activity. We mutated serine and threonine residues in the putative activation segment of the SLK catalytic...

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Identifiers

PMID: 22203681
DOI: 10.1074/jbc.M111.302018
PMCID: PMC3285323

Genes

SLK

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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