Article

Dancing Molecules: Rewiring Cooperative Communications within 14-3-3 ζ Docking Proteins

2019-06-27

Abstract excerpt

Allosteric engineering may play a key role in novel drug discovery. As allosteric interactions are often associated with disease states where protein active sites are rendered constitutively active. Due to their role in regulating signal transduction in cells, we attempted to rewire cooperative communications within the 14-3-3 ζ docking protein. To avoid disruption of evolutionarily tuned interaction networks, we...

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Literature Corpus work: d32cd1d1-dedd-5c78-a704-b00f2d28479b
DOI: 10.1101/683466

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