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Article

Advanced MD Simulation Methods Uncover Mechanisms of SH3 Domain Functions in Small GTPase Signaling.

Proteins - 1 Dec 2025

Yildiz Muslum

Abstract excerpt

The protein complex comprising the SH3 domain and DLC1 proteins plays a vital role in various cellular processes and diseases, including cancer. Essential dynamics for the stability of this complex, which cannot be elucidated by static X-ray crystal structures, have significant implications for understanding cellular physiology and critical diseases. We thoroughly investigated this complex using advanced...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40568771
DOI: 10.1002/prot.70006

Genes

DLC1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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