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Article

Characterizing the role of ensemble modulation in mutation-induced changes in binding affinity.

Journal of the American Chemical Society - 20 May 2009

Manson Anthony, Whitten Steven T, Ferreon Josephine C, Fox Robert O, Hilser Vincent J

Abstract excerpt

Protein conformational fluctuations are key contributors to biological function, mediating important processes such as enzyme catalysis, molecular recognition, and allosteric signaling. To better understand the role of conformational fluctuations in substrate/ligand recognition, we analyzed, experimentally and computationally, the binding reaction between an SH3 domain and the recognition peptide of its partner...

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Identifiers

PMID: 19397330
DOI: 10.1021/ja809133u
PMCID: PMC2711448

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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