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Article

Disruption of the HPA-axis through corticosterone-release pellets induces robust depressive-like behavior and reduced BDNF levels in mice.

Neuroscience letters - 28 Jul 2016

Demuyser Thomas, Bentea Eduard, Deneyer Lauren, Albertini Giulia, Massie Ann, Smolders Ilse

Abstract excerpt

The corticosterone mouse model is widely used in preclinical research towards a better understanding of mechanisms of major depression. One particular administration procedure is the subcutaneous implantation of corticosterone slow-release pellets. In this report we want to provide basic evidence, regarding behavioral changes, neurotransmitter and -modulator levels and some other relevant biomolecules after...

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Source

Identifiers

PMID: 27208833
DOI: 10.1016/j.neulet.2016.05.026

Genes

BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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