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Article

Converging translational evidence for the involvement of the serotonin 2A receptor gene in major depressive disorder.

Progress in neuro-psychopharmacology & biological psychiatry - 3 Oct 2014

Petit Anne-Cécile, Quesseveur Gaël, Gressier Florence, Colle Romain, David Denis J, Gardier Alain M, Ferreri Florian, Lépine Jean-Pierre, Falissard Bruno, Verstuyft Céline, Guiard Bruno P, Corruble Emmanuelle

Abstract excerpt

An association between serotonin 2A receptor (5-HT2AR), encoded by HTR2A gene, and major depressive disorder (MDD) has been suggested. Here, we combined preclinical and ecological clinical approaches to explore the impact of impaired 5-HT2AR-mediated transmission on MDD or anxio-depressive-like phenotype in mice. Htr2a knock-out mice (Htr2a(-/-)) and wild-type mice were compared for the ability of chronic...

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Identifiers

PMID: 24801750
DOI: 10.1016/j.pnpbp.2014.04.013

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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