Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice.

PloS one - 1 Jan 2014

Heiden Susi, Vignon-Zellweger Nicolas, Masuda Shigeru, Yagi Keiko, Nakayama Kazuhiko, Yanagisawa Masashi, Emoto Noriaki

Abstract excerpt

BACKGROUND: Endothelin-1 participates in the pathophysiology of heart failure. The reasons for the lack of beneficial effect of endothelin antagonists in heart failure patients remain however speculative. The anti-apoptotic properties of ET-1 on cardiomyocytes could be a reasonable explanation. We therefore hypothesized that blocking the pro-apoptotic TNF-α pathway using pentoxifylline could prevent the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aorta
Share to Cardiomegaly

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Echocardiography

Share to Endothelin-1

Share to Endothelium, Vascular

Share to Heart Failure

Share to Heart Rate

Source

Open in PubMed Open full text

Identifiers

PMID: 24523936
DOI: 10.1371/journal.pone.0088730
PMCID: PMC3921186

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vascular endothelium derived endothelin-1 is required for normal heart function after chronic pressure overload in mice.PMID 24523936Read ↗

Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice.Semantic proximity Read ↗

Endothelial deletion of protein tyrosine phosphatase-1B protects against pressure overload-induced heart failure in mice.Semantic proximity Read ↗

Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis.Semantic proximity Read ↗

Angiotensin II type 1a receptor signalling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy.Semantic proximity Read ↗

Impact of volume overload on cardiac connexin-43 and extracellular matrix of normotensive and hypertensive Ren-2 transgenic rats: Effects of treatment with Trandolapril and LosartanSemantic proximity Read ↗

Dexrazoxane prevents the development of the impaired cardiac phenotype in caveolin-1-disrupted mice.Semantic proximity Read ↗

Electrical remodelling precedes heart failure in an endothelin-1-induced model of cardiomyopathy.Semantic proximity Read ↗

Anti-tumor necrosis factor-alpha antibody limits heart failure in a transgenic model.Semantic proximity Read ↗

Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy.Semantic proximity Read ↗

Cardiac-specific knockout and pharmacological inhibition of Endothelin receptor type B lead to cardiac resistance to extreme hypoxia.Semantic proximity Read ↗

Targeted deletion of MMP-9 attenuates myocardial contractile dysfunction in heart failure.Semantic proximity Read ↗

Variable phenotype in murine transverse aortic constriction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.