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Article

Conditional cardiac overexpression of endothelin-1 induces inflammation and dilated cardiomyopathy in mice.

Circulation - 20 Jan 2004

Yang Li L, Gros Robert, Kabir M Golam, Sadi Almuktafi, Gotlieb Avrum I, Husain Mansoor, Stewart Duncan J

Abstract excerpt

BACKGROUND: Myocardial expression of endothelin-1 (ET-1) and its receptors ET(A) and ET(B) is increased in heart failure. However, the role of ET-1 and its signaling pathways in the pathogenesis of myocardial diseases is unclear. METHODS AND RESULTS: Human ET-1 cDNA was placed downstream of a pro...

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Source

Identifiers

PMID: 14718401
DOI: 10.1161/01.CIR.0000105701.98663.D4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14718401-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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