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Article

Genetic inactivation of prokineticin receptor-1 leads to heart and kidney disorders.

Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2011

Boulberdaa Mounia, Turkeri Gulen, Urayama Kyoji, Dormishian Mojdeh, Szatkowski Cécilia, Zimmer Luc, Messaddeq Nadia, Laugel Virginie, Dollé Pascal, Nebigil Canan G

Abstract excerpt

OBJECTIVE: Prokineticins are potent angiogenic hormones that use 2 receptors, prokineticin receptor-1 (PKR1) and PKR2, with important therapeutic use in anticancer therapy. Observations of cardiac and renal toxicity in cancer patients treated with antiangiogenic compounds led us to explore how PKR1 signaling functioned in heart and kidney in vivo. METHODS AND RESULTS: We generated mice with a conditional...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21273561
DOI: 10.1161/ATVBAHA.110.222323

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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