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Article

Overexpression of A kinase interacting protein 1 attenuates myocardial ischaemia/reperfusion injury but does not influence heart failure development.

Cardiovascular research - 1 Aug 2016

Booij Harmen G, Yu Hongjuan, De Boer Rudolf A, van de Kolk Cees W A, van de Sluis Bart, Van Deursen Jan M, Van Gilst Wiek H, Silljé Herman H W, Westenbrink B Daan

Abstract excerpt

AIMS: A kinase interacting protein 1 (AKIP1) stimulates physiological growth in cultured cardiomyocytes and attenuates ischaemia/reperfusion (I/R) injury in ex vivo perfused hearts. We aimed to determine whether AKIP1 modulates the cardiac response to acute and chronic cardiac stresses in vivo. METHODS AND RESULTS: Transgenic mice with cardiac-specific overexpression of AKIP1 (AKIP1-TG) were created. AKIP1-TG...

Read the complete abstract on PubMed

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Share to Hemodynamics
Share to Hypertrophy, Left Ventricular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitochondria, Heart

Share to Mitochondrial Membrane Transport Proteins

Share to Myocardial Reperfusion Injury

Share to Poly A

Share to Ventricular Function, Left

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Source

Identifiers

PMID: 27302402
DOI: 10.1093/cvr/cvw161

Genes

AKIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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