Back to search

Article

Genetic architecture of telomere length in 462,675 UK Biobank whole-genome sequences

2023-09-18

Abstract excerpt

Telomeres protect the ends of chromosomes from damage, and genetic regulation of their length is associated with human disease and ageing. We developed a joint telomere length (TL) metric, combining both qPCR and whole genome sequencing (WGS) measurements across 462,675 UK Biobank participants that increased our ability to capture TL heritability by 36% (h 2 mean= 0.058 to h 2 combined= 0.079) and improved predi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d005f986-cf23-52a8-99fe-3c9ac3971b23
DOI
10.1101/2023.09.18.23295715
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Genetic architecture of telomere length in 462,675 UK Biobank whole-genome sequencesDOI 10.1101/2023.09.18.23295715
Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences.Semantic proximity
Polygenic basis and biomedical consequences of telomere length variationSemantic proximity
Genetic determinants of telomere length from 109,122 ancestrally diverse whole-genome sequences in TOPMedSemantic proximity
Polygenic basis and biomedical consequences of telomere length variationSemantic proximity
Genetically predicted telomere length is associated with clonal somatic copy number alterations in peripheral leukocytesSemantic proximity
Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMedSemantic proximity
Genetic associations with human longevity are enriched for oncogenic genesSemantic proximity
Inherited causes of clonal haematopoiesis in 97,691 whole genomes.Semantic proximity
Genomic, phenomic, and geographic associations of leukocyte telomere length in the United StatesSemantic proximity
Genetic associations with human longevity are enriched for oncogenic genesSemantic proximity
Genomic, phenomic and geographic associations of leukocyte telomere length in the United States.Semantic proximity
Telomeres and Human Disease.Semantic proximity
Select a neighboring publication to make it the new centre.