Article
Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2016
Ojha Juhi, Codd Veryan, Nelson Christopher P, Samani Nilesh J, Smirnov Ivan V, Madsen Nils R, Hansen Helen M, de Smith Adam J, Bracci Paige M, Wiencke John K, Wrensch Margaret R, Wiemels Joseph L, Walsh Kyle M
Abstract excerpt
BACKGROUND: Chronic lymphocytic leukemia (CLL) is the most common leukemia in the Western world. Shorter mean telomere length in leukemic cells has been associated with more aggressive disease. Germline polymorphisms in telomere maintenance genes affect telomere length and may contribute to CLL susceptibility. METHODS: We collected genome-wide data from two groups of patients with CLL (N = 273) and two control...
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