Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans

21 Sept 2012

Abstract excerpt

Leukocyte telomere length (LTL) is associated with a number of common age-related diseases and is a heritable trait. Previous genome-wide association studies (GWASs) identified two loci on chromosomes 3q26.2 (TERC) and 10q24.33 (OBFC1) that are associated with the inter-individual LTL variation. We performed a meta-analysis of 9190 individuals from six independent GWAS and validated our findings in 2226...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Genetics, Aging, and Longevity in Model Organisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23001564
DOI: 10.1093/hmg/dds382

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humansPMID 23001564Read ↗

Identification of seven loci affecting mean telomere length and their association with disease.Semantic proximity Read ↗

Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia.Semantic proximity Read ↗

Common variants near TERC are associated with mean telomere length.Semantic proximity Read ↗

Novel genetic determinants of telomere length from a trans-ethnic analysis of 109,122 whole genome sequences in TOPMedSemantic proximity Read ↗

Telomere structure and maintenance gene variants and risk of five cancer types.Semantic proximity Read ↗

Genome wide association and linkage analyses identified three loci—4q25, 17q23.2, and 10q11.21—associated with variation in leukocyte telomere length: the Long Life Family StudySemantic proximity Read ↗

Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers.Semantic proximity Read ↗

An emerging role for the conserved telomere component 1 (CTC1) in human genetic disease.Semantic proximity Read ↗

Genome-wide association identifies OBFC1 as a locus involved in human leukocyte telomere biology.Semantic proximity Read ↗

Genetic architecture of telomere length in 462,666 UK Biobank whole-genome sequences.Semantic proximity Read ↗

Genetic architecture of telomere length in 462,675 UK Biobank whole-genome sequencesSemantic proximity Read ↗

Detailed assessment of rare and common TERT variation in a family with a telomere biology disorder.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.