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Article

The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells.

European journal of immunology - 1 Apr 2003

Workman Creg J, Vignali Dario A A

Abstract excerpt

The lymphocyte activation gene-3 (LAG-3, CD223) is a CD4-related, activation-induced cell surface molecule that binds to MHC class II with high affinity. The function of murine LAG-3 on T cells is unclear. Here, we show that V beta 7/8(+)LAG-3(-/-) T cells expand poorly following staphylococcal enterotoxin B (SEB) stimulation in vitro. LAG-3(-/-) T cells proliferate at a normal rate, but exhibit increased cell...

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Source

Identifiers

PMID: 12672063
DOI: 10.1002/eji.200323382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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