Article
Independent modes of natural killing distinguished in mice lacking Lag3.
Science (New York, N.Y.) - 19 Apr 1996
Miyazaki T, Dierich A, Benoist C, Mathis D
Abstract excerpt
The LAG3 protein has several features in common with CD4, suggesting that it may be important in controlling T cell reactivity. However, mice with a Lag3 null mutation have now been shown to exhibit a defect in the natural killer cell, rather than the T cell, compartment. Killing of certain tumor targets by natural killer cells from these mice was inhibited or even abolished, whereas lysis of cells displaying...
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