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Roles, function and relevance of LAG3 in HIV infection

17 Jan 2019

Abstract excerpt

HIV causes several forms of immune dysfunction that need to be addressed in a functional cure for HIV.Immune exhaustion describes a dysfunctional phenotype caused by chronic cellular activation.Lymphocyte activation gene-3 (LAG3) is one of several negative coreceptors known as immune checkpoints that contribute to this exhaustion phenotype.Antibodies targeting immune checkpoints are now used clinically to restore...

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PMID: 30653605
DOI: 10.1371/journal.ppat.1007429

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