Article
Autoantibody presentation in drug-induced liver injury and idiopathic autoimmune hepatitis: the influence of human leucocyte antigen alleles.
Pharmacogenetics and genomics - 1 Sept 2016
Stephens Camilla, Castiella Agustin, Gomez-Moreno Eva M, Otazua Pedro, López-Nevot Miguel-Ángel, Zapata Eva, Ortega-Alonso Aida, Ruiz-Cabello Francisco, Medina-Cáliz Inmaculada, Robles-Díaz Mercedes, Soriano German, Roman Eva, Hallal Hacibe, Moreno-Planas José M, Prieto Martin, Andrade Raúl J, Lucena M Isabel
Abstract excerpt
OBJECTIVES: Positive autoantibody (AAB) titres are commonly encountered in autoimmune hepatitis (AIH) and in a proportion of drug-induced liver injury (DILI) patients. The underlying mechanism for selective AAB occurrence in DILI is unknown, but could be associated with variations in immune-associated genes. Hence, we aimed to analyse human leucocyte antigen (HLA) allele compositions in DILI with positive (+) and...
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