Article
Genetic factors affect the etiology, clinical characteristics and outcome of autoimmune hepatitis.
Clinical journal of gastroenterology - 1 Dec 2015
Umemura Takeji, Ota Masao
Abstract excerpt
Autoimmune hepatitis (AIH) is characterized by chronic inflammation of the liver, hypergammaglobulinemia, the presence of serum autoantibodies, histologic evidence of interface hepatitis, and a favorable response to immunosuppressive treatment. Although the etiology of AIH remains undefined, human leukocyte antigen (HLA) class II alleles have been associated with disease onset for decades. AIH resistance and...
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