Article
HLA-related genetic susceptibility in autoimmune hepatitis according to autoantibody profile.
Frontiers in immunology - 1 Jan 2022
Cancado Eduardo Luiz Rachid, Goldbaum-Crescente Juliana, Terrabuio Debora Raquel B
Abstract excerpt
Although the prevalence of autoimmune hepatitis in first-degree relatives is small, the relationship between genetic markers, especially human leucocyte antigens (HLA), and susceptibility to this disease, has been studied for over three decades. The genetic susceptibility to AIH is believed to be different in the two subtypes of the disease, AIH type 1 and AIH type 2. Type 1 AIH has anti-smooth muscle and...
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