Article
Human Leukocyte Antigen Profile Predicts Severity of Autoimmune Liver Disease in Children of European Ancestry.
Hepatology (Baltimore, Md.) - 1 Oct 2021
Ma Yun, Su Haibin, Yuksel Muhammed, Longhi Maria Serena, McPhail Mark J, Wang Pengyun, Bansal Sanjay, Wong Guan-Wee, Graham Jonathon, Yang Li, J Thompson Richard, Doherty Derek G, Hadzic Nedim, Zen Yoh, Quaglia Alberto, Heneghan Michael A, Samyn Marianne, Vergani Diego, Mieli-Vergani Giorgina
Abstract excerpt
BACKGROUND AND AIMS: Genetic predisposition to autoimmune hepatitis (AIH) in adults is associated with possession of human leukocyte antigen (HLA) class I (A*01, B*08) and class II (DRB1*03, -04, -07, or -13) alleles, depending on geographic region. Juvenile autoimmune liver disease (AILD) comprises AIH-1, AIH-2, and autoimmune sclerosing cholangitis (ASC), which are phenotypically different from their adult...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.