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Article

HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity.

PloS one - 1 Jan 2013

Stephens Camilla, López-Nevot Miguel-Ángel, Ruiz-Cabello Francisco, Ulzurrun Eugenia, Soriano Germán, Romero-Gómez Manuel, Moreno-Casares Antonia, Lucena M Isabel, Andrade Raúl J

Abstract excerpt

BACKGROUND AND AIM: The genotype-phenotype interaction in drug-induced liver injury (DILI) is a subject of growing interest. Previous studies have linked amoxicillin-clavulanate (AC) hepatotoxicity susceptibility to specific HLA alleles. In this study we aimed to examine potential associations between HLA class I and II alleles and AC DILI with regards to phenotypic characteristics, severity and time to onset in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23874514
DOI: 10.1371/journal.pone.0068111
PMCID: PMC3706603

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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